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Ghrhtm1.1(cre)Mgmj
Targeted Allele Detail
Summary
Symbol: Ghrhtm1.1(cre)Mgmj
Name: growth hormone releasing hormone; targeted mutation 1.1, Martin G Myers, Jr
MGI ID: MGI:6197216
Synonyms: GhrhCre
Gene: Ghrh  Location: Chr2:157171417-157189426 bp, - strand  Genetic Position: Chr2, 78.25 cM
Alliance: Ghrhtm1.1(cre)Mgmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:264547
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Ghrhtm1.1(cre)Mgmj expression driven by 1 gene
 
Mutation details: A targeting construct was designed to replace the stop codon of the growth hormone releasing hormone (Ghrh) gene with a viral P2A oligopeptide, from porcine teschovirus-1, fused to a Cre recombinase gene. A frt-flanked neomycin resistance (neo) cassette inserted downstream. The construct was electroporated into R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts and resulting chimeric mice were bred with B6.129S4-Gt(ROSA)26Sor/J mice to remove the neo cassette. (J:264547)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ghrh (mouse)
Summary of all recombinase alleles driven by Ghrh.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ghrh Mutation:  14 strains or lines available
References
Original:  J:264547 Rupp AC, et al., Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance. Mol Metab. 2018 Jun 6;
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory