About   Help   FAQ
Ly6atm2.1(cre/Esr1*)Jmol
Targeted Allele Detail
Summary
Symbol: Ly6atm2.1(cre/Esr1*)Jmol
Name: lymphocyte antigen 6 family member A; targeted mutation 2.1, Jeffery D Molkentin
MGI ID: MGI:6198591
Synonyms: Ly6aMerCreMer
Gene: Ly6a  Location: Chr15:74866726-74869880 bp, - strand  Genetic Position: Chr15, 34.29 cM
Alliance: Ly6atm2.1(cre/Esr1*)Jmol page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:264764
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ly6atm2.1(cre/Esr1*)Jmol expression driven by 1 gene
 
Mutation details: A cDNA encoding a MerCreMer fusion protein and an FRT-flanked neomycin cassette were recombined in-frame with the Ly6a ATG start codon (exon 2) via homologous recombination in embryonic stem (ES) cells. The MerCreMer double fusion protein incorporates a cre recombinase cDNA sequence flanked by mutated murine estrogen receptor (mer) ligand binding domains (amino acids 281-599, G525R). Resultant mice were crossed with Flpe mice to delete the neomycin cassette. Expression of Ly6a is eliminated in the targeted allele. (J:264764)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ly6a (mouse)
Summary of all recombinase alleles driven by Ly6a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ly6a Mutation:  22 strains or lines available
References
Original:  J:264764 Vagnozzi RJ, et al., Genetic Lineage Tracing of Sca-1(+) Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation. 2018 Jul 10;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory