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Tg(SMN2-SMN1*T274I)5Ahmb
Transgene Detail
Summary
Symbol: Tg(SMN2-SMN1*T274I)5Ahmb
Name: transgene insertion 5, Arthur H M Burghes
MGI ID: MGI:6199465
Synonyms: SMNT274I
Transgene: Tg(SMN2-SMN1*T274I)5Ahmb  Location: unknown  
Alliance: Tg(SMN2-SMN1*T274I)5Ahmb page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Tg(SMN2-SMN1*T274I)5Ahmb expresses 1 gene
 
Mutation details: The construct is designed with a human SMN1 cDNA carrying the p.Thr274Ile missense mutation in exon 6 under the control of the 4.1 kb human SMN2 promoter. Founder line 5 carries five copies of the transgene. (J:265815)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:265815 Iyer CC, et al., Mild SMN missense alleles are only functional in the presence of SMN2 in mammals. Hum Mol Genet. 2018 Oct 1;27(19):3404-3416
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory