Spatc1l<em1Choc> Endonuclease-mediated Allele Detail MGI Mouse (MGI:6200789)

Spatc1l^em1Choc
Endonuclease-mediated Allele Detail

Summary

Symbol:	Spatc1l^em1Choc
Name:	spermatogenesis and centriole associated 1 like; endonuclease-mediated mutation 1, Chunghee Cho
MGI ID:	MGI:6200789
Gene:	Spatc1l Location: Chr10:76398106-76406035 bp, + strand Genetic Position: Chr10, 39.2 cM
Alliance:	Spatc1l^em1Choc page

Mutation
origin

Strain of Origin:

C57BL/6N

Mutation
description

Allele Type:		Endonuclease-mediated (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: CRISPR/Cas9 mediated recombination created a 178 bp deletion in exon 1 spanning the ATG start site. PCR and immunoblot analysis confirmed the absence of RNA and protein expression in testes from homozygous mice. (J:265193)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Spatc1l Mutation:	17 strains or lines available

References

Original:	J:265193 Kim J, et al., SPATC1L maintains the integrity of the sperm head-tail junction. EMBO Rep. 2018 Sep;19(9)
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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