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Hcrttm1.1(cre)Ldl
Targeted Allele Detail
Summary
Symbol: Hcrttm1.1(cre)Ldl
Name: hypocretin; targeted mutation 1, Luis de Lecea
MGI ID: MGI:6201351
Synonyms: Hcrt-Cre, Hcrt-IRES-Cre
Gene: Hcrt  Location: Chr11:100652519-100653757 bp, - strand  Genetic Position: Chr11, 63.6 cM
Alliance: Hcrttm1.1(cre)Ldl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:264534
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Hcrttm1.1(cre)Ldl expression driven by 1 gene
 
Mutation details: Bacterial artificial chromosome clones containing the preprohypocretin (Hcrt) gene were used to target a cassette containing the internal ribosomal entry sequence (IRES) linked to Cre recombinase and a Frt-flanked neomycin resistance gene immediately downstream of the exon 2 stop codon. The target construct was electroporated into C57BL/6 embryonic stem cells, targeted clones were injected into blastocysts, and resultantchimeras were bred for germline transmission and then crossed with Flp-deletion mice to remove the neomycin selection gene. (J:264534)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hcrt (mouse)
Summary of all recombinase alleles driven by Hcrt.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcrt Mutation:  19 strains or lines available
References
Original:  J:264534 Giardino WJ, et al., Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nat Neurosci. 2018 Aug;21(8):1084-1095
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory