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Albem1(dre/ERT2)Bzsh
Endonuclease-mediated Allele Detail
Summary
Symbol: Albem1(dre/ERT2)Bzsh
Name: albumin; endonuclease-mediated mutation 1, Bin Zhou
MGI ID: MGI:6202045
Synonyms: Alb-DreER
Gene: Alb  Location: Chr5:90608756-90624461 bp, + strand  Genetic Position: Chr5, 44.7 cM
Alliance: Albem1(dre/ERT2)Bzsh page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Albem1(dre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: The line was generated by inserting a cDNA encoding IRES-Dre recombinase fused with a mutant form of estrogen receptor hormon-binding domaine C (ERT2) into in-frame with the translational termination codon of the last coding exon of Alb by homologous recombination using the CRISPR/Cas9 technology. This knock-in strategy leads to simultaneous expression of DreER and endogenous albumin. (J:263751)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Alb (mouse)
Summary of all recombinase alleles driven by Alb.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alb Mutation:  97 strains or lines available
References
Original:  J:263751 Wang Y, et al., Genetic tracing of hepatocytes in liver homeostasis, injury, and regeneration. J Biol Chem. 2017 May 26;292(21):8594-8604
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory