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Usp10tm2.1Fuj
Targeted Allele Detail
Summary
Symbol: Usp10tm2.1Fuj
Name: ubiquitin specific peptidase 10; targeted mutation 2.1, Masahiro Fujii
MGI ID: MGI:6220871
Synonyms: Usp10fl
Gene: Usp10  Location: Chr8:120637099-120684299 bp, + strand  Genetic Position: Chr8, 68.61 cM, cytoband E1
Alliance: Usp10tm2.1Fuj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:266271
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. This allele was used to generate Usp10tm1Fuj (J:266271)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Usp10 Mutation:  58 strains or lines available
References
Original:  J:266271 Higuchi M, et al., USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells. Stem Cell Reports. 2016 Dec 13;7(6):1116-1129
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory