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Ighg1em1(cre/ERT2)Rsky
Endonuclease-mediated Allele Detail
Summary
Symbol: Ighg1em1(cre/ERT2)Rsky
Name: immunoglobulin heavy constant gamma 1 (G1m marker); endonuclease-mediated mutation 1, Klaus Rajewsky
MGI ID: MGI:6266867
Synonyms: Cgamma1-CreERT2
Gene: Ighg1  Location: Chr12:113290161-113294143 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance: Ighg1em1(cre/ERT2)Rsky page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ighg1em1(cre/ERT2)Rsky expression driven by 1 gene
 
Mutation details: Single guide RNAs and a targeting vector, designed to insert an internal ribosomal entry site (IRES) followed by a cre/ERT2 fusion gene into the 3' untranslated region of the immunoglobulin heavy constant gamma 1 (Ighg1) gene, and the Cas9 nuclease were introduced into the cytoplasm of C57BL/6NCrl fertilized eggs with well recognized pronuclei. (J:267281)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ighg1 (mouse)
Summary of all recombinase alleles driven by Ighg1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ighg1 Mutation:  28 strains or lines available
References
Original:  J:267281 Weber T, et al., A novel allele for inducible Cre expression in germinal center B cells. Eur J Immunol. 2018 Oct 25;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory