Tg(TG-cre/ERT2)248Ubc
Transgene Detail
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| Symbol: |
Tg(TG-cre/ERT2)248Ubc |
| Name: |
transgene insertion 248, Uppsala University |
| MGI ID: |
MGI:6267050 |
| Synonyms: |
TGcreERT2, TG-Cre-ERT2 #248, Tg(Tg-cre/ERT2)248 |
| Transgene: |
Tg(TG-cre/ERT2)248Ubc Location: unknown
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| Alliance: |
Tg(TG-cre/ERT2)248Ubc page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(TG-cre/ERT2)248Ubc expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| cattle |
TG (280706) |
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Mutation details: This transgene contains a 2-kb bovine thyroglobulin promoter sequence driving expression of Cre recombinase fused to a modified ligand-binding domain (LBD) of the human estrogen receptor that binds and thus is induced by tamoxifen or 4-hydroxytamoxifen, but not estrogen. Reverse transcription-polymerase chain reaction (RT-PCR) analysis amplified a cre/ERT2 fragment from thyroid tissue of two transgenic founder mice, designated F248 and F300. Northern blot analysis confirmed transgene expression in the thyroid glands, but not in other analyzed tissues, of transgenic mice.
(J:267412)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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TG
(cattle)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:267412 Roswall P, Taking pressure of anaplastic thyroid carcinoma: Molecular studies of apoptosis and interstitial hypertension (Doctoral dissertation). PhD Thesis - Uppsala University. 2006; |
| All: |
1 reference(s) |
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Analysis Tools
