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Procrtm1(cre/ERT2)Yaz
Targeted Allele Detail
Summary
Symbol: Procrtm1(cre/ERT2)Yaz
Name: protein C receptor, endothelial; targeted mutation 1, Yi Arial Zeng
MGI ID: MGI:6273782
Synonyms: ProcrCreERT2, ProcrCreERT2-IRES-tdTomato
Gene: Procr  Location: Chr2:155593037-155597391 bp, + strand  Genetic Position: Chr2, 77.26 cM, cytoband H1-3
Alliance: Procrtm1(cre/ERT2)Yaz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Procrtm1(cre/ERT2)Yaz expression driven by 1 gene
 
Mutation detailsAn inducible cre recombinase fusion gene (cre/ERT2), IRES, tdTomato reporter gene and FRT-flanked neomycin resistance cassette were inserted at the translation initiation site. (J:217483)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Procr (mouse)
Summary of all recombinase alleles driven by Procr.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Procr Mutation:  17 strains or lines available
Notes
The version of this allele that does not contain the neomycin selection cassette, Procrtm1.1(Cre/ERT2)Yaz, has been analyzed.
References
Original:  J:217483 Wang D, et al., Identification of multipotent mammary stem cells by protein C receptor expression. Nature. 2015 Jan 1;517(7532):81-4
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory