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Kittm1(cre)Htng
Targeted Allele Detail
Summary
Symbol: Kittm1(cre)Htng
Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Hiroki Taniguchi
MGI ID: MGI:6279770
Synonyms: c-kitIRES-Cre
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Kittm1(cre)Htng page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:245913
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Kittm1(cre)Htng expression driven by 1 gene
 
Mutation details: A targeting vector containing IRES-cre coding sequence followed by a polyadenylation signal sequence, and a FRT site flanked PGK-neo cassette was inserted immediately following the stop codon in exon 21 of the targeted Kit gene. The construct was electroporated into embryonic stem (ES) cells. Chimeric mice were generated by aggregating correctly targeted ES cells by tetraploid complementation. The resulting chimeric animals were tested for germline transmission. (J:245913)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Kit (mouse)
Summary of all recombinase alleles driven by Kit.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  182 strains or lines available
References
Original:  J:245913 Amat SB, et al., Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice. PLoS One. 2017;12(6):e0179347
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory