Tie1tm1(icre/Esr1*)Hrr
Targeted Allele Detail
|
|
| Symbol: |
Tie1tm1(icre/Esr1*)Hrr |
| Name: |
tyrosine kinase with immunoglobulin-like and EGF-like domains 1; targeted mutation 1.1, Hans-Reimer Rodewald |
| MGI ID: |
MGI:6279994 |
| Synonyms: |
Tie1MiCreM Neo, Tie1tm1(icre/Esr1*)Aug |
| Gene: |
Tie1 Location: Chr4:118328388-118347046 bp, - strand Genetic Position: Chr4, 54.67 cM
|
| Alliance: |
Tie1tm1(icre/Esr1*)Hrr page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:250996
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
Not Specified
|
|
| Allele Type: |
|
Targeted (Inducible, Recombinase) |
| Inducer: |
|
tamoxifen |
| Mutation: |
|
Insertion
|
| |
|
Tie1tm1(icre/Esr1*)Hrr expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Tie1 (MGI:99906) |
|
|
| |
|
Mutation details: A tamoxifen-inducible codon-improved Cre recombinase (iCre) flanked by two mutated estrogen receptor sites (MeriCreMer) and FRT-flanked Neo cassette was inserted into the first exon of the Tie1 locus in embryonic stem cells to express the fusion protein MeriCreMer under the control of the endogenous Tie1 promoter.
(J:250996)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Tie1
(mouse)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Tie1 Mutation: |
68 strains or lines available
|
|
| Original: |
J:250996 Savant S, et al., The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep. 2015 Sep 22;12(11):1761-73 |
| All: |
1 reference(s) |
|
Analysis Tools
