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Cmastm1.2Bwei
Targeted Allele Detail
Summary
Symbol: Cmastm1.2Bwei
Name: cytidine monophospho-N-acetylneuraminic acid synthetase; targeted mutation 1.2, Birgit Weinhold
MGI ID: MGI:6281181
Synonyms: Cmas-
Gene: Cmas  Location: Chr6:142702468-142721440 bp, + strand  Genetic Position: Chr6, 74.66 cM
Alliance: Cmastm1.2Bwei page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:271312
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 4. The neo cassette was removed through subsequent flp-mediated recombination. Exon 4 was deleted through subsequent cre-mediated deletion. (J:271312)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cmas Mutation:  28 strains or lines available
References
Original:  J:271312 Abeln M, et al., Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro. Chembiochem. 2017 Jul 4;18(13):1305-1316
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory