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Htr3atm1.1(flpo)Rudy
Targeted Allele Detail
Summary
Symbol: Htr3atm1.1(flpo)Rudy
Name: 5-hydroxytryptamine (serotonin) receptor 3A; targeted mutation 1.1, Bernardo Rudy
MGI ID: MGI:6284821
Synonyms: Htr3a-ires-Flpo
Gene: Htr3a  Location: Chr9:48810513-48822399 bp, - strand  Genetic Position: Chr9, 26.53 cM
Alliance: Htr3atm1.1(flpo)Rudy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:269094
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Htr3atm1.1(flpo)Rudy expression driven by 1 gene
 
Mutation details: The targeting vector contains, from 5' to 3', an internal ribosome entry site sequence (IRES), the FLPo recombinase sequence (with nuclear localization signal at its 5' end), a bovine growth hormone polyA sequence and a lox2272-flanked PGK-Neo-bGHpA cassette inserted into the 3'UTR immediately following the STOP codon of the gene. Cre-mediated recombination removed the floxed neo cassette. (J:269094)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Htr3a (mouse)
Summary of all recombinase alleles driven by Htr3a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr3a Mutation:  36 strains or lines available
References
Original:  J:269094 Schuman B, et al., Four Unique Interneuron Populations Reside in Neocortical Layer 1. J Neurosci. 2019 Jan 2;39(1):125-139
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory