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Grptm1.1(EGFP/cre)Zfc
Targeted Allele Detail
Summary
Symbol: Grptm1.1(EGFP/cre)Zfc
Name: gastrin releasing peptide; targeted mutation 1.1, Zhou-Feng Chen
MGI ID: MGI:6285760
Synonyms: GrpCre-KI
Gene: Grp  Location: Chr18:66005891-66019667 bp, + strand  Genetic Position: Chr18, 38.98 cM
Alliance: Grptm1.1(EGFP/cre)Zfc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:288162
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase, Reporter)
Mutation:    Insertion
 
Grptm1.1(EGFP/cre)Zfc expression driven by 1 gene
 
Mutation details: The targeting vector was designed to insert an enhanced green fluorescent protein sequence (EGFP) fused to a Cre Recombinase sequence (cre) followed by a FRT-flanked neomycin cassette into the exon 1 ATG start codon of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. Immunohistochemistry and RNA in situ hybridization confirms the absence of Grp. (J:288162)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Grp (mouse)
Summary of all recombinase alleles driven by Grp.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grp Mutation:  30 strains or lines available
References
Original:  J:288162 Barry DM, et al., Exploration of Sensory and Spinal Neurons Expressing GRP in Itch and Pain. bioRxiv. 2018;
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory