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Gene Expression Data
Assay Details
Assay
Reference: J:82121 Luque JM, et al., Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain Res Dev Brain Res. 2003 Feb 16;140(2):195-203
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6295355
Gene symbol: Dab1
Gene name: disabled 1
Antibody: anti-mDab1 B3
Results
Specimen 1A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cerebral cortex ventricular layer Present Uniform 1A
TS20: cortical preplate Present Regionally restricted 1A Radiated fibers spanning the preplate were clearly labeled.

Specimen not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex ventricular layer Present Uniform
TS22: cerebral cortex Present Regionally restricted Expression was detected in ascending processes towards the marginal zone contacting the pial surface.

Specimen 1D: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: telencephalon Present Non-Uniform 1D Labelling resembling radial glia was noted throughout the telencephalon. Particularly intense staining was detected in the corticostriatal sulcus and in reciprocal thalamo-cortical projections.
TS24: cerebral cortex intermediate zone Present 1D
TS24: cerebral cortex marginal layer Present 1D
TS24: cortical plate Present 1D

Specimen 1G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: brain Present 1G

Specimen 1H: embryonic day 12.5; Dab1tm1Cpr/Dab1tm1Cpr (more )
Structure Level Pattern Image Note
TS20: brain Absent 1H

Specimen 2A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: zona limitans intrathalamica Present 2A Expression signal was found in processes and cell bodies.

Specimen 4A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex ventricular layer Present 4A

Specimen 4B: embryonic day 14.5; Relnrl-Orl/Relnrl-Orl (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Present Regionally restricted 4B Expression was increased in the outermost cortical region of the reeler mutant.
TS22: cerebral cortex ventricular layer Weak 4B

Specimen not shown: embryonic day 14.5; Relnrl-Orl/Relnrl-Orl (more )
Structure Level Pattern Image Note
TS22: cerebellum Present
TS22: neocortex Present
TS22: thalamus Present
TS22: allocortex Present Regionally restricted An accumulation of signal was observed in the paleocortex of the mutant.

Specimen 5A: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cortical layer IV Present 5A Expression was detected in pyramidal neurons along with the proximal part of their apical dendrite.
TS28: cortical layer V Present 5A Expression was detected in pyramidal neurons along with the proximal part of their apical dendrite.

Specimen 5B: postnatal adult; Relnrl-Orl/Relnrl-Orl (more )
Structure Level Pattern Image Note
TS28: neocortex Present 5B Beyond the cell positioning defect in the mutant, immunoreactivity illustrates how apical dendrites lost their proper orientation.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory