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Fgf10tm2.1(cre/ERT2)Sbel
Targeted Allele Detail
Summary
Symbol: Fgf10tm2.1(cre/ERT2)Sbel
Name: fibroblast growth factor 10; targeted mutation 2.1, Saverio Bellusci
MGI ID: MGI:6296741
Synonyms: Fgf10Cre-ERT2, Fgf10Ki-v2, Fgf10tm2(eYFP-Cre/ERT2)Sbel
Gene: Fgf10  Location: Chr13:118851199-118928651 bp, + strand  Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
Alliance: Fgf10tm2.1(cre/ERT2)Sbel page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:308431
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Fgf10tm2.1(cre/ERT2)Sbel expression driven by 1 gene
 
Mutation details: An EGFP gene and inducible cre/ERT2 fusion were inserted into the 3' UTR immediately downstream of the stop codon of the exon 3. The self-cleavage LF2A and T2A sequences will lead to 3 distinct proteins. Flp-mediated recombination removed the selection cassette. The homozygous embryos suffered from lung and limb agenesis and the analysis of Fgf10 expression by qPCR indicated a drastic reduction in Fgf10 expression. It is a loss-of-function allele. (J:308431)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Fgf10 (mouse)
Summary of all recombinase alleles driven by Fgf10.
 

Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf10 Mutation:  33 strains or lines available
Notes
S3 = C57BL/6NCrl
References
Original:  J:308431 Chu X, et al., Validation of a Novel Fgf10 (Cre-ERT2) Knock-in Mouse Line Targeting FGF10(Pos) Cells Postnatally. Front Cell Dev Biol. 2021;9:671841
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory