About   Help   FAQ
Gt(ROSA)26Sortm2.1(UBC-flpe)Ozg
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2.1(UBC-flpe)Ozg
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Ozgene
MGI ID: MGI:6297051
Synonyms: OzFlp, Ubic-Flpe
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2.1(UBC-flpe)Ozg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:274081
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Gt(ROSA)26Sortm2.1(UBC-flpe)Ozg expression driven by 1 gene
 
Mutation details: A flpe recombinase transgene, driven by the human ubiquitin C promoter, was inserted into intron 1. Downstream of the gene the transgene cassette also contains bovine growth hormone (BGH) polyadenylation signal sequence and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed by breeding to cre allele carying mice. (J:274081)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: UBC (human)
Summary of all recombinase alleles driven by UBC.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:274081 Rashidi M, et al., CD52 inhibits Toll-like receptor activation of NF-kappaB and triggers apoptosis to suppress inflammation. Cell Death Differ. 2018 Feb;25(2):392-405
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory