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Slc6a3tm1.1(flpo)Fuyu
Targeted Allele Detail
Summary
Symbol: Slc6a3tm1.1(flpo)Fuyu
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1.1, Fu Yu
MGI ID: MGI:6316964
Gene: Slc6a3  Location: Chr13:73684866-73726791 bp, + strand  Genetic Position: Chr13, 40.1 cM
Alliance: Slc6a3tm1.1(flpo)Fuyu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:340041
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Slc6a3tm1.1(flpo)Fuyu expression driven by 1 gene
 
Mutation details: The DAT-ires-Flpo targeting construct was designed to insert a loxN-flanked neomycin resistance (neo) cassette followed by an internal ribosomal entry site (IRES) and a Flpo recombinase sequence downstream of the stop codon of the solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (Slc6a3) gene. Correctly targeted ES cells were injected into blastocysts and the resulting chimeric males were bred to CMV-cre mice to remove the neo cassette. (J:101977, J:340041)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc6a3 (mouse)
Summary of all recombinase alleles driven by Slc6a3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:  66 strains or lines available
References
Original:  J:340041 Yang T, et al., Plastic and stimulus-specific coding of salient events in the central amygdala. Nature. 2023 Apr;616(7957):510-519
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory