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Mecomtm4.1(cre/ERT2)Aspe
Targeted Allele Detail
Summary
Symbol: Mecomtm4.1(cre/ERT2)Aspe
Name: MDS1 and EVI1 complex locus; targeted mutation 4.1, Archibald Perkins
MGI ID: MGI:6317371
Synonyms: Mds1CreERT2, Mds1m2
Gene: Mecom  Location: Chr3:30005445-30563937 bp, - strand  Genetic Position: Chr3, 12.66 cM
Alliance: Mecomtm4.1(cre/ERT2)Aspe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292941
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Modified isoform(s), Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mecomtm4.1(cre/ERT2)Aspe expression driven by 1 gene
 
Mutation details: Tamoxifen-inducible cre/ERT2 and an FRT-flanked neomycin cassette were introduced to exon 1 of the mouse Mecom gene via homologous recombination in embryonic stem (ES) cells. Resultant mice were crossed with Flp-expressing mice to emoved the selection cassette. (J:101977, J:292941, J:310645)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mecom (mouse)
Summary of all recombinase alleles driven by Mecom.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mecom Mutation:  81 strains or lines available
References
Original:  J:292941 Christodoulou C, et al., Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. 2020 Feb;578(7794):278-283
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory