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Fcgr1tm1.1(icre)Ciphe
Targeted Allele Detail
Summary
Symbol: Fcgr1tm1.1(icre)Ciphe
Name: Fc receptor, IgG, high affinity I; targeted mutation 1.1, Centre d'ImmunoPhenomique
MGI ID: MGI:6330739
Synonyms: Fcgr1-cre, Fcgr1tm2Ciph
Gene: Fcgr1  Location: Chr3:96190225-96201285 bp, - strand  Genetic Position: Chr3, 41.72 cM
Alliance: Fcgr1tm1.1(icre)Ciphe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:274437
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Fcgr1tm1.1(icre)Ciphe expression driven by 1 gene
 
Mutation details: An IRES-iCRE-2A-TEAL-frt-neoR-frt cassette was introduced in the 3' untranslated region of the Fcgr1 gene, downstream of the stop codon by homologous recombination. Upon germline transmission, mice were then crossed to mice expressing the site-specific recombinase to delete the frt-flanked neoR cassette. (J:274437)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Fcgr1 (mouse)
Summary of all recombinase alleles driven by Fcgr1.
 

Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcgr1 Mutation:  35 strains or lines available
References
Original:  J:274437 Scott CL, et al., The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages. Immunity. 2018 Aug 21;49(2):312-325.e5
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory