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Ly6gtm2621(cre)Arte
Targeted Allele Detail
Summary
Symbol: Ly6gtm2621(cre)Arte
Name: lymphocyte antigen 6 family member G; targeted mutation 2621, TaconicArtemis
MGI ID: MGI:6330745
Synonyms: Ly6gtm1.1(cre)Gunz, Ly6gtm2621(cre,-tdTomato)Arte, Ly6g(tm2621(CretdTomato)Arte
Gene: Ly6g  Location: Chr15:75027110-75030977 bp, + strand  Genetic Position: Chr15, 34.29 cM, cytoband E1
Alliance: Ly6gtm2621(cre)Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227159
Parent Cell Line:  ART B6 3.6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase, Reporter)
Mutation:    Insertion
 
Ly6gtm2621(cre)Arte expression driven by 1 gene
 
Mutation details: The Ly6g coding sequence in exon 1 and the splice donor site at the junction of exon 1 and intron 1 were replaced with a cassette containing the open reading frame of Cre recombinase and tdTomato separated by a self-splicing T2A peptide. A human growth hormone polyadenylation signal was inserted at the 3' end of the Cre-T2A-tdTomato sequence in order to prevent downstream transcription of the remaining mouse Ly6g. The FRT flanked positive selection marker (puromycin resistance (PuroR)) was removed after the successful generation of transgenic mice by crossing with Flpe expressing mice. (J:227159)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ly6g (mouse)
Summary of all recombinase alleles driven by Ly6g.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ly6g Mutation:  22 strains or lines available
References
Original:  J:227159 Hasenberg A, et al., Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nat Methods. 2015 May;12(5):445-52
All:  32 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory