Defa4tm1.1(cre)Fya
Targeted Allele Detail
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| Symbol: |
Defa4tm1.1(cre)Fya |
| Name: |
defensin, alpha, 4; targeted mutation 1.1, Felix Yarovinsky |
| MGI ID: |
MGI:6331073 |
| Synonyms: |
aDefensin-4-IRES-Cre |
| Gene: |
Defa4 Location: unknown Genetic Position: Chr8, Syntenic
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| Alliance: |
Defa4tm1.1(cre)Fya page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:273741
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Defa4tm1.1(cre)Fya expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Defa4 (MGI:99584) |
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Mutation details: The targeting vector was generated to insert Frt-flanked neo selection cassette and IRES-cre into the exon 2 of the defensin alpha 4 (Defa4) gene. Resulting mice were crossed with FloO deleter to remove the neo selection cassette. Cre expression is restricted in Paneth cell in the intestines.
(J:273741)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Defa4
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Defa4 Mutation: |
0 strains or lines available
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| Original: |
J:273741 Burger E, et al., Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation. Cell Host Microbe. 2018 Feb 14;23(2):177-190.e4 |
| All: |
4 reference(s) |
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Analysis Tools
