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Dmrt3em1(cre)Kldr
Endonuclease-mediated Allele Detail
Summary
Symbol: Dmrt3em1(cre)Kldr
Name: doublesex and mab-3 related transcription factor 3; endonuclease-mediated mutation 1, Klas Kullander
MGI ID: MGI:6331094
Synonyms: Dmrt3Cre
Gene: Dmrt3  Location: Chr19:25587665-25601285 bp, + strand  Genetic Position: Chr19, 20.5 cM
Alliance: Dmrt3em1(cre)Kldr page
Mutation
origin
Strain of Origin:  B6D2F1
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Dmrt3em1(cre)Kldr expression driven by 1 gene
 
Mutation details: Zinc finger nuclease mRNAs designed for the Dmrt3 locus, and a donor vector carrying iCre and 2A peptide sequence were introduced to B6D2F1 zygotes by pronuclear microinjection. The 2A peptide coding sequence allows for cotranslation of the Dmrt3 promoter-driven iCre followed by Dmrt3. (J:273477)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dmrt3 (mouse)
Summary of all recombinase alleles driven by Dmrt3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dmrt3 Mutation:  12 strains or lines available
References
Original:  J:273477 Perry S, et al., Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits. J Neurosci. 2019 Mar 6;39(10):1771-1782
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory