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Col1a1tm22Nki
Targeted Allele Detail
Summary
Symbol: Col1a1tm22Nki
Name: collagen, type I, alpha 1; targeted mutation 22, The Netherlands Cancer Institute
MGI ID: MGI:6342019
Synonyms: Col1A1tm22(RMCE)Nki
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm22Nki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:293819
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (RMCE-ready)
Mutation:    Insertion
 
Mutation detailsThe ES cells were targeted in the 3' UTR of the Col1a1 locus with a RMCE construct containing F3-PGK-PuroTK-frt. The targeted Col1a1 locus can later be used as a docking site for the introduction of a plasmid, minimally containing a costitutive promoter, the desired transgene sequence and F3/frt sites. (J:293819)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  163 strains or lines available
References
Original:  J:293819 Bresser K, et al., A mouse model that is immunologically tolerant to reporter and modifier proteins. Commun Biol. 2020 May 29;3(1):273
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/09/2024
MGI 6.24
The Jackson Laboratory