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Sftpctm1(dre/ERT2)Bzsh
Targeted Allele Detail
Summary
Symbol: Sftpctm1(dre/ERT2)Bzsh
Name: surfactant associated protein C; targeted mutation 1, Bin Zhou
MGI ID: MGI:6357171
Synonyms: Sftpc-DreER
Gene: Sftpc  Location: Chr14:70758389-70761521 bp, - strand  Genetic Position: Chr14, 36.32 cM
Alliance: Sftpctm1(dre/ERT2)Bzsh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:278107
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Sftpctm1(dre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: A targeting vector containing DreER cDNA, SV40 poly(A) sequence and Frt site-flanked PGK-EM7-Neo resistance gene was used to insert a cDNA encoding Dre recombinase fused with a mutant form of the estrogen-receptor hormone-binding domain in frame with the translational start codon (ATG) of the Sftpc gene. (J:278107)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sftpc (mouse)
Summary of all recombinase alleles driven by Sftpc.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sftpc Mutation:  24 strains or lines available
References
Original:  J:278107 Liu Q, et al., Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet. 2019 Apr;51(4):728-738
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory