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Siglechtm1.1(icre)Ciphe
Targeted Allele Detail
Summary
Symbol: Siglechtm1.1(icre)Ciphe
Name: sialic acid binding Ig-like lectin H; targeted mutation 1.1, Centre d'ImmunoPhenomique
MGI ID: MGI:6357988
Synonyms: Siglech-iCre
Gene: Siglech  Location: Chr7:55417926-55428673 bp, + strand  Genetic Position: Chr7, 33.42 cM
Alliance: Siglechtm1.1(icre)Ciphe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:267220
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Siglechtm1.1(icre)Ciphe expression driven by 1 gene
 
Mutation details: The cassette encoding improved Cre (iCre) gene was inserted in the 3' non-coding region of mouse Siglech gene. The initiation of iCre gene translation was under the control of internal ribosome entry site (IRES) sequences. FRT flanked neo selection cassette was removed by breeding mouse with mice expressing Flippase O in the germline. (J:267220)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Siglech (mouse)
Summary of all recombinase alleles driven by Siglech.
 

Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Siglech Mutation:  24 strains or lines available
References
Original:  J:267220 Tomasello E, et al., Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection. EMBO J. 2018 Oct 1;37(19)
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory