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Dbhtm1.1(flpo)Pjen
Targeted Allele Detail
Summary
Symbol: Dbhtm1.1(flpo)Pjen
Name: dopamine beta hydroxylase; targeted mutation 1.1, Patricia Jensen
MGI ID: MGI:6358815
Synonyms: DbhFlpo
Gene: Dbh  Location: Chr2:27055519-27073216 bp, + strand  Genetic Position: Chr2, 19.29 cM
Alliance: Dbhtm1.1(flpo)Pjen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Dbhtm1.1(flpo)Pjen expression driven by 1 gene
 
Mutation details: A targeting vector containing a Flpo-poly(A) cassette and a loxP-flanked PGK/Em7-Neo cassette was used to replace 107 bp of exon 1 of the gene. Cre-mediated recombination removed the floxed neo cassette. (J:198264)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dbh (mouse)
Summary of all recombinase alleles driven by Dbh.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dbh Mutation:  17 strains or lines available
Notes
The version of this allele that contains the neomycin selection cassette, Dbhtm1(flpo)Pjen, has been analyzed.
References
Original:  J:198264 Robertson SD, et al., Developmental origins of central norepinephrine neuron diversity. Nat Neurosci. 2013 Aug;16(8):1016-23
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory