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Tcerg1ltm1.1(cre/ERT2)Zjh
Targeted Allele Detail
Summary
Symbol: Tcerg1ltm1.1(cre/ERT2)Zjh
Name: transcription elongation regulator 1-like; targeted mutation 1.1, Z Josh Huang
MGI ID: MGI:6360921
Synonyms: Tcerg1l-CreER
Gene: Tcerg1l  Location: Chr7:137810703-137999459 bp, - strand  Genetic Position: Chr7, 82.95 cM
Alliance: Tcerg1ltm1.1(cre/ERT2)Zjh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:323692
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tcerg1ltm1.1(cre/ERT2)Zjh expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a CreER fusion gene followed by a frt-flanked neo cassette upstream of the stop codon of the Tcerg1l (transcription elongation regulator 1-like) gene. CreER incorporates cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand-binding domain. The neomycin cassette was excised with Flp recombinase. (J:323692)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tcerg1l (mouse)
Summary of all recombinase alleles driven by Tcerg1l.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcerg1l Mutation:  34 strains or lines available
References
Original:  J:323692 Matho KS, et al., Genetic dissection of the glutamatergic neuron system in cerebral cortex. Nature. 2021 Oct;598(7879):182-187
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory