About   Help   FAQ
Cdkn1aem3(cre/ERT)Smoc
Endonuclease-mediated Allele Detail
Summary
Symbol: Cdkn1aem3(cre/ERT)Smoc
Name: cyclin dependent kinase inhibitor 1A; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
MGI ID: MGI:6361244
Synonyms: P21-CreER
Gene: Cdkn1a  Location: Chr17:29309953-29319696 bp, + strand  Genetic Position: Chr17, 15.12 cM
Alliance: Cdkn1aem3(cre/ERT)Smoc page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Cdkn1aem3(cre/ERT)Smoc expression driven by 1 gene
 
Mutation details: A CreER cDNA was inserted into the stop codon of the gene. A linker encoding a 2A self-cleaving peptide sequence was inserted upstream of the cre/ERT construct to allow simultaneous expression of CreER and Cdkn1a. (J:278880)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdkn1a (mouse)
Summary of all recombinase alleles driven by Cdkn1a.
 

Expression
In Mice Carrying this Mutation: 30 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn1a Mutation:  63 strains or lines available
References
Original:  J:278880 Li Y, et al., Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth. Cell Res. 2018 Jul;28(7):775-778
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory