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Cdkn1aem3(cre/ERT)Smoc
Endonuclease-mediated Allele Detail
Summary
Symbol: Cdkn1aem3(cre/ERT)Smoc
Name: cyclin dependent kinase inhibitor 1A; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
MGI ID: MGI:6361244
Synonyms: P21-CreER
Gene: Cdkn1a  Location: Chr17:29309953-29319696 bp, + strand  Genetic Position: Chr17, 15.12 cM
Alliance: Cdkn1aem3(cre/ERT)Smoc page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Cdkn1aem3(cre/ERT)Smoc expression driven by 1 gene
 
Mutation details: A CreER cDNA was inserted into the stop codon of the gene. A linker encoding a 2A self-cleaving peptide sequence was inserted upstream of the cre/ERT construct to allow simultaneous expression of CreER and Cdkn1a. (J:278880)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdkn1a (mouse)
Summary of all recombinase alleles driven by Cdkn1a.
 

Expression
In Mice Carrying this Mutation: 30 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn1a Mutation:  63 strains or lines available
References
Original:  J:278880 Li Y, et al., Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth. Cell Res. 2018 Jul;28(7):775-778
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory