Nrg1em1(cre/ERT2)Bzsh
Endonuclease-mediated Allele Detail
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| Symbol: |
Nrg1em1(cre/ERT2)Bzsh |
| Name: |
neuregulin 1; endonuclease-mediated mutation 1, Bin Zhou |
| MGI ID: |
MGI:6361462 |
| Synonyms: |
Nrg1-CreER |
| Gene: |
Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
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| Alliance: |
Nrg1em1(cre/ERT2)Bzsh page
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Endonuclease-mediated (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Nrg1em1(cre/ERT2)Bzsh expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Nrg1 (MGI:96083) |
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Mutation details: The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. A complementary DNA encoding Cre recombinase fused with a mutant form of the ESR hormone-binding domain (CreERT2) followed by a polyadenylation sequence, was inserted into the last coding exon of Nrg1 gene, and a 2A peptide sequence was used to link the Nrg1 coding region and CreERT2 cDNA to allow expression of both Nrg1 and CreERT2.
(J:278094)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Nrg1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nrg1 Mutation: |
54 strains or lines available
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| Original: |
J:278094 Pu W, et al., Genetic Targeting of Organ-Specific Blood Vessels. Circ Res. 2018 Jun 22;123(1):86-99 |
| All: |
1 reference(s) |
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Analysis Tools
