About   Help   FAQ
Nrg1em2(cre/ERT2)Bzsh
Endonuclease-mediated Allele Detail
Summary
Symbol: Nrg1em2(cre/ERT2)Bzsh
Name: neuregulin 1; endonuclease-mediated mutation 2, Bin Zhou
MGI ID: MGI:6361465
Synonyms: Nrg1-CrexER
Gene: Nrg1  Location: Chr8:32299493-33381858 bp, - strand  Genetic Position: Chr8, 18.75 cM
Alliance: Nrg1em2(cre/ERT2)Bzsh page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Nrg1em2(cre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. A complementary DNA encoding Cre recombinase fused with 2 rox sequences flanking a mutant form of the ESR hormone-binding domain (ERT2) was inserted into the translational start codon ATG of the Nrg1 gene and followed by a polyadenylation sequences. (J:278094)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nrg1 (mouse)
Summary of all recombinase alleles driven by Nrg1.
 

Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  54 strains or lines available
References
Original:  J:278094 Pu W, et al., Genetic Targeting of Organ-Specific Blood Vessels. Circ Res. 2018 Jun 22;123(1):86-99
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory