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Gene Expression Data
Assay Details
Assay
Reference: J:108723 Andersson O, et al., Synergistic interaction between Gdf1 and Nodal during anterior axis development. Dev Biol. 2006 May 15;293(2):370-81
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6363335
Gene symbol: Nodal
Gene name: nodal growth differentiation factor
Reporter: lacZ
Direct Detection
Results
Specimen 5A: embryonic day 7.5; Nodaltm1Rob/Nodaltm1Rob (more )
Note: Late headfold
Structure Level Pattern Image Note
TS11: node Present 5A
TS11: lateral plate mesoderm Present Regionally restricted 5A Expression in left side of lateral plate mesoderm.
Specimen 5C Nodal+/-: embryonic day 6.5; Nodaltm1Rob/Nodaltm1Rob (more )
Note: Early streak
Structure Level Pattern Image Note
TS9: embryo Present Regionally restricted 5C Nodal+/- Expression in epiblast.
Specimen 5C Gdf1-/- Nodal+/-: embryonic day 6.5; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Note: Early streak
Structure Level Pattern Image Note
TS9: embryo Present Regionally restricted 5C Gdf1-/- Nodal+/- Expression in epiblast. Authors report no downregulation of expression in absence of Gdf1.
Specimen 5D Nodal+/-: embryonic day 8.0; Nodaltm1Rob/Nodaltm1Rob (more )
Note: 5-8 somite stage
Structure Level Pattern Image Note
TS12: node Present 5D Nodal+/-
TS12: lateral plate mesoderm Present Regionally restricted 5D Nodal+/- Expression in left side of lateral plate mesoderm.
Specimen 5D Gdf1-/- Nodal+/-: embryonic day 8.0; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Note: 5-8 somite stage
Structure Level Pattern Image Note
TS12: node Present 5D Gdf1-/- Nodal+/- No significant downregulateion of expression in the node.
TS12: lateral plate mesoderm Trace Regionally restricted 5D Gdf1-/- Nodal+/- Expression drastically downregulated in left side of lateral plate mesoderm.
Specimen 5E: embryonic day 10.0; Nodaltm1Rob/Nodaltm1Rob (more )
Structure Level Pattern Image Note
TS16: 1st branchial pouch Present Regionally restricted 5E Expression in first branchial pouch at border between first and second branchial arches.
Specimen 5F: embryonic day 10.0; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Structure Level Pattern Image Note
TS16: 1st branchial pouch Present Regionally restricted 5F Expression not affected by absence of Gdf1, despite obvious malformation of 1st branchial arch in double mutant.
Specimen 5G: embryonic day 10.0; Nodaltm1Rob/Nodaltm1Rob (more )
Structure Level Pattern Image Note
TS16: future forebrain roof plate Present 5G
Specimen 5H: embryonic day 10.0; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Structure Level Pattern Image Note
TS16: future forebrain roof plate Present Regionally restricted 5H Expression detected in roofplate in embryo with holoprosencephaly, but not extending into forebrain vesicle.
Specimen 5I: embryonic day 10.0; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Structure Level Pattern Image Note
TS16: future brain Present Regionally restricted 5I Expression detected in embryo with exencephaly, but confined to edges of neural tube that did not close.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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