Prph2tm2.1Itl
Targeted Allele Detail
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| Symbol: |
Prph2tm2.1Itl |
| Name: |
peripherin 2; targeted mutation 2.1, inGenious Targeting Laboratory |
| MGI ID: |
MGI:6367783 |
| Synonyms: |
N229S-RDS, Prph2N |
| Gene: |
Prph2 Location: Chr17:47221404-47235859 bp, + strand Genetic Position: Chr17, 22.91 cM
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| Alliance: |
Prph2tm2.1Itl page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:276288
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Not Specified) |
| Mutations: |
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Insertion, Single point mutation
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Mutation details: Two point mutations were introduced to exon 2 of the gene. The first was a silent G>A to eliminate a Hha1 restriction site to aid in genotyping, and the second was the A>G missense mutation to produce the p.N229S substitution in the encoded protein. An FRT site flanked neomycin selection cassette was removed via flp-mediated recombination.
(J:276288)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Prph2 Mutation: |
28 strains or lines available
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| Original: |
J:276288 Stuck MW, et al., Retinal Degeneration Slow (RDS) Glycosylation Plays a Role in Cone Function and in the Regulation of RDS.ROM-1 Protein Complex Formation. J Biol Chem. 2015 Nov 13;290(46):27901-13 |
| All: |
3 reference(s) |
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Analysis Tools
