Ren1tm2.2Sig
Targeted Allele Detail
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| Symbol: |
Ren1tm2.2Sig |
| Name: |
renin 1 structural; targeted mutation 2.2, Curt Sigmund |
| MGI ID: |
MGI:6368628 |
| Synonyms: |
renin-bnull |
| Gene: |
Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
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| Alliance: |
Ren1tm2.2Sig page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:278974
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| Parent Cell Line: |
iTL IC1 (ES Cell)
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| Strain of Origin: |
C57BL/6NTac
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| Allele Type: |
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Targeted (Modified isoform(s)) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 1b. An additional loxP site was inserted downstream of exon 1b. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 1b. Mice fail to express the brain isoform (renin-b), but express the kideny isoform (renin-a).
(J:278974)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ren1 Mutation: |
35 strains or lines available
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| Original: |
J:278974 Shinohara K, et al., Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension. 2016 Dec;68(6):1385-1392 |
| All: |
4 reference(s) |
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Analysis Tools
