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Bhlhe22tm1(flpo)Sros
Targeted Allele Detail
Summary
Symbol: Bhlhe22tm1(flpo)Sros
Name: basic helix-loop-helix family, member e22; targeted mutation 2, Sarah Ross
MGI ID: MGI:6369826
Synonyms: Bhlhb5::flpo
Gene: Bhlhe22  Location: Chr3:18108489-18111678 bp, + strand  Genetic Position: Chr3, 4.98 cM, cytoband A2
Alliance: Bhlhe22tm1(flpo)Sros page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234119
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Bhlhe22tm1(flpo)Sros expression driven by 1 gene
 
Mutation details: The coding region of the gene was replaced with coding sequence for Flpo recombinase. An adjacent loxP-flanked neomycin selection cassette was removed via Cre-mediated recombination in the germline. (J:234119)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Bhlhe22 (mouse)
Summary of all recombinase alleles driven by Bhlhe22.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bhlhe22 Mutation:  12 strains or lines available
References
Original:  J:234119 Cai X, et al., Bhlhb5::flpo allele uncovers a requirement for Bhlhb5 for the development of the dorsal cochlear nucleus. Dev Biol. 2016 Jun 15;414(2):149-60
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory