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Pdgfratm1.1(cre/ERT2)Trdo
Targeted Allele Detail
Summary
Symbol: Pdgfratm1.1(cre/ERT2)Trdo
Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 1.1, Thomas A Rando
MGI ID: MGI:6377446
Synonyms: PDGFRalphaCreER
Gene: Pdgfra  Location: Chr5:75312953-75358876 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Pdgfratm1.1(cre/ERT2)Trdo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:280557
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Pdgfratm1.1(cre/ERT2)Trdo expression driven by 1 gene
 
Mutation details: A targeting vector was designed to place a FRT-flanked neo cassete in intron 3 and CreERT2 minigene inserted after ATG start codon in exon 4 of the mouse PDGFRa locus. The neo marker was subsequently removed by crossing Flp deleter mouse. (J:280557)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdgfra (mouse)
Summary of all recombinase alleles driven by Pdgfra.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfra Mutation:  88 strains or lines available
References
Original:  J:280557 Wosczyna MN, et al., Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle. Cell Rep. 2019 May 14;27(7):2029-2035.e5
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory