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Col1a1tm3(tetO-Ccne1)Jvd
Targeted Allele Detail
Summary
Symbol: Col1a1tm3(tetO-Ccne1)Jvd
Name: collagen, type I, alpha 1; targeted mutation 3, Jan MA van Deursen
MGI ID: MGI:6379359
Synonyms: Ccne1T, Ccne1T18, Ccne1T20, Col1a1tm1(tetO-Ccne1-HA)Jvd
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm3(tetO-Ccne1)Jvd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:281613
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Epitope tag, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Col1a1tm3(tetO-Ccne1)Jvd expresses 1 gene
 
Mutation detailsRMCE on KH2 cells replaced the FRT-flanked neo cassette with a cassette that contains a splice acceptor, polyadenylation sequence and the tetracycline promoter driving inducible expression of an HA-tagged cDNA for mouse Ccne1 followed by a polyadenylation sequence and hygromycin resistance cassette with an FRT site. (J:281613)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  163 strains or lines available
References
Original:  J:281613 Aziz K, et al., Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice. Gastroenterology. 2019 Jul;157(1):210-226.e12
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory