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Gdf15tm1(cre/ERT2)Amc
Targeted Allele Detail
Summary
Symbol: Gdf15tm1(cre/ERT2)Amc
Name: growth differentiation factor 15; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:6382101
Synonyms: Gdf15nuGFP-CE
Gene: Gdf15  Location: Chr8:71082043-71085106 bp, - strand  Genetic Position: Chr8, 34.15 cM, cytoband C1
Alliance: Gdf15tm1(cre/ERT2)Amc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:294071
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gdf15tm1(cre/ERT2)Amc expression driven by 1 gene
 
Mutation details: Recombinase mediated cassette exchange (RMCE) replaced the fragment between FRT and the third loxP which contained lacZ , neomycin and exon 2 sequences located in intron 1 of the Gdf15 allele with the following - an FRT site, En2 splice acceptor, P2A, nuclear GFP, F2A, cre/ERT2, polyA and a rox-flanked puromycin resistance cassette followed by a loxP site. (J:101977, J:294071)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gdf15 (mouse)
Summary of all recombinase alleles driven by Gdf15.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gdf15 Mutation:  27 strains or lines available
References
Original:  J:294071 Liu J, et al., Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2020 Apr;31(4):701-715
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory