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Slc6a5tm1.1(cre)Ksak
Targeted Allele Detail
Summary
Symbol: Slc6a5tm1.1(cre)Ksak
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5; targeted mutation 1.1, Kenji Sakimura
MGI ID: MGI:6382286
Synonyms: GLYT2Cre, Slc6a5tm1.1(cre)Yyan
Gene: Slc6a5  Location: Chr7:49559894-49613604 bp, + strand  Genetic Position: Chr7, 31.71 cM, cytoband B3
Alliance: Slc6a5tm1.1(cre)Ksak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:279620
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Slc6a5tm1.1(cre)Ksak expression driven by 1 gene
 
Mutation details: A Cre cDNA, a polyadenylation signal (pA) from the human granulocyte-colony stimulating factor gene, a phosphoglycerate kinase (PGK) promoter-driven neomycin resistance gene (neo)-pA cassette (PGK-neo-pA cassette) flanked by two frt sites were inserted into the translation initiation site (in exon 2) of the mouse Slc6a5 gene by homologous recombination in ES cells. The PGK-neo-pA cassette was removed by crossing mice with FLP66 transgenic mice. (J:279620)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc6a5 (mouse)
Summary of all recombinase alleles driven by Slc6a5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a5 Mutation:  59 strains or lines available
References
Original:  J:279620 Kakizaki T, et al., A glycine transporter 2-Cre knock-in mouse line for glycinergic neuron-specific gene manipulation. IBRO Rep. 2017 Dec;3:9-16
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory