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Robo3tm1.1(cre)Ajaw
Targeted Allele Detail
Summary
Symbol: Robo3tm1.1(cre)Ajaw
Name: roundabout guidance receptor 3; targeted mutation 1.1, Alexander Jaworski
MGI ID: MGI:6385305
Synonyms: Robo3Cre
Gene: Robo3  Location: Chr9:37327341-37344730 bp, - strand  Genetic Position: Chr9, 20.76 cM, cytoband B
Alliance: Robo3tm1.1(cre)Ajaw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:282827
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Robo3tm1.1(cre)Ajaw expression driven by 1 gene
 
Mutation details: A targeting construct was generated by a combination of gene synthesis and recombineering. The Cre coding sequence and a frt-flanked neomycin (Neo) cassette were inserted into exon 1 of the Robo3 locus to replace the endogenous translation initiation codon and subsequent 31 nucleotides. The Neo cassette was subsequently deleted by crossing the chimeras to FLPe mice. (J:282827)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Robo3 (mouse)
Summary of all recombinase alleles driven by Robo3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Robo3 Mutation:  76 strains or lines available
References
Original:  J:282827 Tulloch AJ, et al., Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3(Cre) mouse. J Comp Neurol. 2019 Dec 15;527(18):2948-2972
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory