Tg(TK-cre/Hif1a)#Dmgi
Transgene Detail
|
|
| Symbol: |
Tg(TK-cre/Hif1a)#Dmgi |
| Name: |
transgene insertion, Daniele M Gilkes |
| MGI ID: |
MGI:6385533 |
| Synonyms: |
4xHRE-CRE-ODD |
| Transgene: |
Tg(TK-cre/Hif1a)#Dmgi Location: unknown
|
| Alliance: |
Tg(TK-cre/Hif1a)#Dmgi page
|
|
| Strain of Origin: |
Not Specified
|
|
| Transgene Type: |
|
Transgenic (Recombinase) |
| Inducer: |
|
hypoxia |
| Mutation: |
|
Insertion
|
| |
|
Tg(TK-cre/Hif1a)#Dmgi expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
TK |
|
|
| |
|
Mutation details: The transgene contains 4 repeats of a synthetic HIF-DNA binding sequence (4xHRE) and TK minimal promoter of unknown origin followed by 770-bps -globin intron drives expression of cre recombinase gene fused with the oxygen-dependent degradation (ODD) domain. This transgene is responsive to hypoxia. Six founder lines were identified. The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:281517)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
TK
(species not specified)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:281517 Godet I, et al., Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis. Nat Commun. 2019 Oct 24;10(1):4862 |
| All: |
1 reference(s) |
|
Analysis Tools
