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Tnni3em1(dre)Bzsh
Endonuclease-mediated Allele Detail
Summary
Symbol: Tnni3em1(dre)Bzsh
Name: troponin I, cardiac 3; endonuclease-mediated mutation 1, Bin Zhou
MGI ID: MGI:6386758
Synonyms: Tnni3-Dre
Gene: Tnni3  Location: Chr7:4521304-4526228 bp, - strand  Genetic Position: Chr7, 2.61 cM
Alliance: Tnni3em1(dre)Bzsh page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Tnni3em1(dre)Bzsh expression driven by 1 gene
 
Mutation details: A cDNA encoding Dre recombinase was iserted into the site encoding the translational start codon of the Krt19 gene, using the CRISPR/Cas9 technology. The woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) were placed after the Dre cDNA sequence to stabilize the Dre-encoding mRNA. (J:278073)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tnni3 (mouse)
Summary of all recombinase alleles driven by Tnni3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnni3 Mutation:  14 strains or lines available
References
Original:  J:278073 He L, et al., Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec;23(12):1488-1498
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory