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Trpa1tm1(flpo)Toka
Targeted Allele Detail
Summary
Symbol: Trpa1tm1(flpo)Toka
Name: transient receptor potential cation channel, subfamily A, member 1; targeted mutation 1, Takaharu Okada
MGI ID: MGI:6387248
Gene: Trpa1  Location: Chr1:14942872-14989086 bp, - strand  Genetic Position: Chr1, 4.5 cM
Alliance: Trpa1tm1(flpo)Toka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:279034
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Trpa1tm1(flpo)Toka expression driven by 1 gene
 
Mutation details: The coding region in the first exon of Trpa1 was replaced with the flippase (Flpo) recombinase gene followed by the SV40 polyA signal and a PGK-Neo cassette flanked by loxP sites. It is a null allele. (J:279034)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Trpa1 (mouse)
Summary of all recombinase alleles driven by Trpa1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpa1 Mutation:  92 strains or lines available
References
Original:  J:279034 Takahashi S, et al., Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development. Sci Rep. 2019 Jun 13;9(1):8625
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory