Tg(TcraY5,TcrbY5)459Tdsc
Transgene Detail
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Symbol: |
Tg(TcraY5,TcrbY5)459Tdsc |
Name: |
transgene insertion 459, Todd Schell |
MGI ID: |
MGI:6391077 |
Synonyms: |
TCR-V |
Transgene: |
Tg(TcraY5,TcrbY5)459Tdsc Location: unknown
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Alliance: |
Tg(TcraY5,TcrbY5)459Tdsc page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(TcraY5,TcrbY5)459Tdsc expresses
2 genes
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Tcra (MGI:98553) |
expresses Valpha4.1-Jalpha18 |
mouse |
Tcrb (MGI:98578) |
expresses Vbeta7-Jbeta1.3 |
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Mutation details: The transgene construct contains sequences from the alpha and beta-chains of the T cell receptor (TCR) from the SV40 large tumor antigen epitope IV-specific cytotoxic T lymphocyte clone Y-5. The TCR subunits express Vbeta7-Jbeta1.3and Valpha4.1-Jalpha18.
(J:284225)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:284225 Otahal P, et al., Inefficient cross-presentation limits the CD8+ T cell response to a subdominant tumor antigen epitope. J Immunol. 2005 Jul 15;175(2):700-12 |
All: |
1 reference(s) |
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