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Col1a1tm1(tetO/CMV-Lep)Rll
Targeted Allele Detail
Summary
Symbol: Col1a1tm1(tetO/CMV-Lep)Rll
Name: collagen, type I, alpha 1; targeted mutation 1, Rudolph L Leibel
MGI ID: MGI:6393313
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm1(tetO/CMV-Lep)Rll page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:283599
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Mutation details: RCME on KH2 cells inserted a cassette that contains the tetracycline response element and CAG promoter driving inducible expression of the mouse Leptin gene followed by the hygromycin B selection gene. (J:283599)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  163 strains or lines available
Notes
This allele was generated with Col1a1tm13(neo/hygro*)Jae.
References
Original:  J:283599 Skowronski AA, et al., Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice. Sci Transl Med. 2020 Jan 1;12(524)
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory