Eif2b5tm1.1Sidr
Targeted Allele Detail
|
|
| Symbol: |
Eif2b5tm1.1Sidr |
| Name: |
eukaryotic translation initiation factor 2B, subunit 5 epsilon; targeted mutation 1.1, Carmela Sidrauski |
| MGI ID: |
MGI:6416103 |
| Synonyms: |
Eif2b5R191H, Eif2b5R191H(flox) |
| Gene: |
Eif2b5 Location: Chr16:20317567-20328073 bp, + strand Genetic Position: Chr16, 12.45 cM
|
| Alliance: |
Eif2b5tm1.1Sidr page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:278928
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
C57BL/6J
|
|
| Allele Type: |
|
Targeted (Conditional ready, Humanized sequence) |
| Mutations: |
|
Insertion, Single point mutation
|
| |
|
Mutation details: A CGC to CAC codon substitution was made in exon 4, changing residue arginine 191 to histamine, loxP sites were inserted flanking exons 3 and 7, and a FRT-flanked neomycin resistance cassette was inserted between exons 2 and 3. The neomycin resistance cassette was removed via flp-mediated recombination. The R191H mutation is homologous to the human R195H mutation that causes an infantile-onset, rapidly progressing form of vanishing white matter.
(J:278928)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Eif2b5 Mutation: |
31 strains or lines available
|
|
| Original: |
J:278928 Wong YL, et al., eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019 Jan 9;8:e42940 |
| All: |
1 reference(s) |
|
Analysis Tools
