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Gene Expression Data
Assay Details
Assay
Reference: J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6416155
Gene symbol: Nf2
Gene name: neurofibromin 2
Antibody: Anti-NF2 (sc-332; C-18)
Assay notes: Two antibodies were described MGI:5551500 and MGI:6407081, but the one used in this assay was not specified. Either antibody could have been used.
Results
Specimen 1A: embryonic day 12.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: red - Nf2; green - Eomes (assay MGI:6416157).
Structure Level Pattern Image Note
TS20: telencephalon Present Regionally restricted 1A right , 1A left Expression was detected in the dorsal and ventral telencephalon.
Specimen 1B: embryonic day 12.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Nf2; green - Eomes (assay MGI:6416157).
Structure Level Pattern Image Note
TS20: telencephalon Present Regionally restricted 1B right , 1B left Expression was specifically lost from the ventricular surface of the dorsal, but not the ventral telencephalon.
Specimen 1E: embryonic day 12.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Triple labeled: red - Nf2; magenta - Ctnnb1 (assay MGI:6416257); green - Tjp1 (assay MGI:6416258).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 1E Merge , 1E Nf2 Expression was concentrated at the apical region of neural progenitor cells.
Specimen 1F: embryonic day 12.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: red - Nf2; magenta - Ctnnb1 (assay MGI:6416257); green - Tjp1 (assay MGI:6416258).
Structure Level Pattern Image Note
TS20: neocortex Trace 1F Nf2 , 1F Merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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