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Ins2tm1.1(cre)Wpiz
Targeted Allele Detail
Summary
Symbol: Ins2tm1.1(cre)Wpiz
Name: insulin II; targeted mutation 1.1, Weiping Zhang
MGI ID: MGI:6423077
Synonyms: Ins2-cre
Gene: Ins2  Location: Chr7:142232393-142233463 bp, - strand  Genetic Position: Chr7, 88.0 cM
Alliance: Ins2tm1.1(cre)Wpiz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:251799
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Ins2tm1.1(cre)Wpiz expression driven by 1 gene
 
Mutation details: An IRES-Cre-bpA DNA sequence and an frt-flanked neomycin selection cassette was inserted between the stop codon ad the 3'UTR in the third exon. The neomycin selection cassette was subsequently removed via FLP-mediated recombination in the germline. (J:251799)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ins2 (mouse)
Summary of all recombinase alleles driven by Ins2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ins2 Mutation:  93 strains or lines available
References
Original:  J:251799 Li L, et al., Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons. Sci Rep. 2016 Feb 2;6:20438
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory