Aldh1a1<tm1.1(cre/ERT2)Cai> Targeted Allele Detail MGI Mouse (MGI:6423547)

Aldh1a1^{tm1.1(cre/ERT2)Cai}
Targeted Allele Detail

Summary

Symbol:	Aldh1a1^{tm1.1(cre/ERT2)Cai}
Name:	aldehyde dehydrogenase family 1, subfamily A1; targeted mutation 1.1, Huaibin Cai
MGI ID:	MGI:6423547
Synonyms:	Aldh1a1^P2A-CreERT2
Gene:	Aldh1a1 Location: Chr19:20470079-20620829 bp, + strand Genetic Position: Chr19, 13.91 cM
Alliance:	Aldh1a1^{tm1.1(cre/ERT2)Cai} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:280705
Parent Cell Line:	JM8A3 (ES Cell)
Strain of Origin:	C57BL/6N-A^tm1Brd

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Aldh1a1^{tm1.1(cre/ERT2)Cai} expression driven by 1 gene

Mutation details: The targeting construct "pDNDF-7-DTA-5 arm-P2A-CreERT2-STOP-Frt-Neo-Frt-3 arm-DTA" replaced the stop codon. Flp-mediated recombination removed the selection cassette. (J:280705)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1a1 (mouse) Summary of all recombinase alleles driven by Aldh1a1. Comparative matrix view of recombinase activities Alliance mouse Aldh1a1 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Aldh1a1 Mutation:	39 strains or lines available

References

Original:	J:280705 Wu J, et al., Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. Cell Rep. 2019 Jul 30;28(5):1167-1181.e7
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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